Comparative Bioavailability Evaluation of Erythromycin Base and Its Salts and Esters. I. Erythromycin Estolate Capsules Versus Enteric-Coated Erythromycin Base Tablets
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چکیده
منابع مشابه
Comparative bioavailability evaluation of erythromycin base and its salts and esters. I. Erythromycin estolate capsules versus enteric-coated erythromycin base tablets.
A randomized crossover study in 16 healthy volunteers given multiple doses of erythromycin base enteric-coated tablets or erythromycin estolate capsules revealed essentially no difference in the resultant plasma concentration of bioactive erythromycin. This similarity in bioactivity persisted despite the fact that total eryghromycin levels (bioactive erythromycin base plus bioinactive erythromy...
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Using prescription-event monitoring to determine whether erythromycin estolate was a more frequent cause of jaundice than erythromycin stearate or tetracycline 12 208 patients, for whom 5343 doctors had prescribed one of the three drugs, were identified by the Prescription Pricing Authority. Of the questionnaires sent to general practitioners about the possible occurrence of jaundice, 76% were ...
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To the Editor: It was disturbing to read the article entitled “Studies of the Stability of 18 Chemical Constituents,” in the December, 1972, issue of Clinical Chemistry (1). The authors define their conditions of collection and storage but do not, however, make it clear what their object is. If the objective was to show stability of serum before analysis, then their data are misleading. For exa...
متن کاملBioavailability and stability of erythromycin delayed release tablets.
BACKGROUND Erythromycin is available as the free base, ethylsuccinate, estolate, stearate, gluceptate, and lactobionate derivatives. When given orally erythromycin and its derivatives except the estolate are inactivated to some extent by the gastric acid and poor absorption may result. OBJECTIVES To establish whether delayed release erythromycin tablets meet the bioequivalent requirement for ...
متن کاملHepatotoxicity of erythromycin estolate during pregnancy.
Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transaminase (SGOT) were determined before and during treatment by a fluorometric meth...
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ژورنال
عنوان ژورنال: The Journal of Clinical Pharmacology
سال: 1980
ISSN: 0091-2700
DOI: 10.1002/j.1552-4604.1980.tb01716.x